Compound Detail
CHEMBL5532185
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Basic Information
| ChEMBL ID | CHEMBL5532185 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VTSIEWHGNUJVTJ-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
197.6
MW (Da)
1.36
ALogP
4
HBA
2
HBD
66.5
PSA (Ų)
0.68
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.7
Kd 1 meas. best 6.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| YTH domain-containing protein 1 CHEMBL5169187 | Kd | 6.84 | 6.84 | 146.0 | 1 |
| YTH domain-containing protein 1 CHEMBL5169187 | IC50 | 5.7 | 5.7 | 2000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| YTH domain-containing protein 1 | Kd | = | 146.0 | nM | 6.84 | Binding affinity to YTHDC1 (unknown origin) assessed as equilibrium dissociation... | 38787793 |
| YTH domain-containing protein 1 | IC50 | = | 2000.0 | nM | 5.7 | Inhibition of YTHDC1 (unknown origin) | 38787793 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38787793 | 10.1021/acs.jmedchem.4c00599 | YTH domain-containing protein 1 | 2 |
Data from ChEMBL 36 via Core Engine