Compound Detail
CHEMBL554206
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CNC(=O)c1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccc4ncc(C)nc34)c2Cl)cc1.Cl
Basic Information
| ChEMBL ID | CHEMBL554206 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AFSNDUSSWFDOIU-KYIGKLDSSA-N |
| Parent Compound | CHEMBL1195281 |
| Active Moiety | CHEMBL1195281 |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
592.5
MW (Da)
4.98
ALogP
6
HBA
2
HBD
113.5
PSA (Ų)
0.27
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| B2 bradykinin receptor CHEMBL4111 | IC50 | 9.0 | 9.0 | 1.0 | 2 |
| B2 bradykinin receptor CHEMBL3157 | IC50 | 8.51 | 8.3567 | 3.1 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| B2 bradykinin receptor | IC50 | = | 1.0 | nM | 9.0 | Concentration required to inhibit specific binding of [ 3H]BK (0.06 nM) to Brady... | 9767643 |
| B2 bradykinin receptor | IC50 | = | 1.0 | nM | 9.0 | In vitro inhibitory activity towards bradykinin receptor B2 using [3H]BK (0.06 n... | 15027853 |
| B2 bradykinin receptor | IC50 | = | 3.1 | nM | 8.51 | Concentration required to inhibit specific binding of [3H]BK (1.2 nM) to A-431 c... | 9767643 |
| B2 bradykinin receptor | IC50 | = | 5.2 | nM | 8.28 | Inhibition specific binding of [3H]BK (1.0 nM) to human Bradykinin receptor B2 w... | 9767643 |
| B2 bradykinin receptor | IC50 | = | 5.2 | nM | 8.28 | In vitro inhibitory activity towards human bradykinin receptor B2 expressed in C... | 15027853 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9767643 | 10.1021/jm980300f | B2 bradykinin receptor | 3 |
| 15027853 | 10.1021/jm030159x | B2 bradykinin receptor | 2 |
Data from ChEMBL 36 via Core Engine