Compound Detail
CHEMBL5542927
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Basic Information
| ChEMBL ID | CHEMBL5542927 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SUZVYLHEGQOFRP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
474.4
MW (Da)
4.60
ALogP
4
HBA
2
HBD
78.5
PSA (Ų)
0.64
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | EC50 | 6.58 | 6.58 | 260.0 | 1 |
| HepG2 CHEMBL395 | EC50 | 4.57 | 4.57 | 26800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | EC50 | = | 260.0 | nM | 6.58 | Antimalarial activity against asexual blood stage Plasmodium falciparum 3D7 asse... | 38554474 |
| HepG2 | EC50 | = | 26800.0 | nM | 4.57 | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability i... | 38554474 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38554474 | 10.1016/j.ejmech.2024.116354 | Plasmodium falciparum | 1 |
| 38554474 | 10.1016/j.ejmech.2024.116354 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine