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Assay Detail

CHEMBL5501229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by Cell Titer-Glo assay
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Autocuration

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein.
Nguyen W, Boulet C, Dans MG, Loi K, Jarman KE, Watson GM, Tham WH, Fairhurst KJ, Yeo T, Fidock DA, Wittlin S, Chowdury M, de Koning-Ward TF, Chen G, Yan D, Charman SA, Baud D, Brand S, Jackson PF, Cowman AF, Gilson PR, Sleebs BE.
Eur J Med Chem (2024) 270 : 116354 -116354
PubMed 38554474 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 42 4.73 5.02

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5558237 1 5.02
CHEMBL5558754 1 4.96
CHEMBL5558877 1 4.85
CHEMBL5558742 1 4.81
CHEMBL5542418 1 4.79
CHEMBL5517851 1 4.71
CHEMBL5556078 1 4.70
CHEMBL5556902 1 4.68
CHEMBL5537071 1 4.61
CHEMBL5542927 1 4.57
CHEMBL5542625 1 4.52
CHEMBL5505780 1 4.50
CHEMBL5542844 1 -
CHEMBL5559320 1 -
CHEMBL5517703 1 -
CHEMBL5556279 1 -
CHEMBL5517651 1 -
CHEMBL5523390 1 -
CHEMBL5559331 1 -
CHEMBL5505877 1 -
CHEMBL5557821 1 -
CHEMBL5557436 1 -
CHEMBL5523383 1 -
CHEMBL5556522 1 -
CHEMBL5542278 1 -
CHEMBL5555638 1 -
CHEMBL5505766 1 -
CHEMBL5558027 1 -
CHEMBL5557215 1 -
CHEMBL5517655 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5558237 EC50 = 9500.0 nM 5.02
CHEMBL5558754 EC50 = 10900.0 nM 4.96
CHEMBL5558877 EC50 = 14000.0 nM 4.85
CHEMBL5558742 EC50 = 15500.0 nM 4.81
CHEMBL5542418 EC50 = 16300.0 nM 4.79
CHEMBL5517851 EC50 = 19300.0 nM 4.71
CHEMBL5556078 EC50 = 19800.0 nM 4.70
CHEMBL5556902 EC50 = 21000.0 nM 4.68
CHEMBL5537071 EC50 = 24500.0 nM 4.61
CHEMBL5542927 EC50 = 26800.0 nM 4.57
CHEMBL5542625 EC50 = 30300.0 nM 4.52
CHEMBL5505780 EC50 = 31500.0 nM 4.50
CHEMBL5517703 EC50 > 40000.0 nM -
CHEMBL5557730 EC50 > 40000.0 nM -
CHEMBL5559320 EC50 > 40000.0 nM -
CHEMBL5542844 EC50 > 40000.0 nM -
CHEMBL532276 EC50 = - nM -
CHEMBL5557938 EC50 > 40000.0 nM -
CHEMBL5505886 EC50 > 40000.0 nM -
CHEMBL5557045 EC50 > 40000.0 nM -
CHEMBL5556478 EC50 > 40000.0 nM -
CHEMBL5556500 EC50 > 40000.0 nM -
CHEMBL5558599 EC50 = - nM -
CHEMBL5559048 EC50 > 40000.0 nM -
CHEMBL5558281 EC50 > 40000.0 nM -
CHEMBL5557840 EC50 > 40000.0 nM -
CHEMBL5527948 EC50 > 40000.0 nM -
CHEMBL5556279 EC50 > 40000.0 nM -
CHEMBL5517651 EC50 > 40000.0 nM -
CHEMBL5523390 EC50 > 40000.0 nM -
CHEMBL5559331 EC50 > 40000.0 nM -
CHEMBL5505877 EC50 > 40000.0 nM -
CHEMBL5557821 EC50 > 40000.0 nM -
CHEMBL5557436 EC50 > 40000.0 nM -
CHEMBL5523383 EC50 > 40000.0 nM -
CHEMBL5556522 EC50 > 40000.0 nM -
CHEMBL5542278 EC50 > 40000.0 nM -
CHEMBL5555638 EC50 > 40000.0 nM -
CHEMBL5505766 EC50 > 40000.0 nM -
CHEMBL5558027 EC50 > 40000.0 nM -
CHEMBL5557215 EC50 > 40000.0 nM -
CHEMBL5517655 EC50 > 40000.0 nM -