Compound Detail
CHEMBL554943
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL554943 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AYULBOXVHKIVEG-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
491.0
MW (Da)
5.11
ALogP
7
HBA
0
HBD
57.6
PSA (Ų)
0.48
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.64
EC50 1 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL218 | Ki | 6.64 | 6.64 | 227.0 | 1 |
| Cannabinoid receptor 1 CHEMBL218 | EC50 | 6.22 | 6.22 | 600.0 | 1 |
| Cannabinoid receptor 2 CHEMBL253 | Ki | 5.41 | 5.41 | 3919.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Ki | = | 227.0 | nM | 6.64 | Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells... | 19520572 |
| Cannabinoid receptor 1 | EC50 | = | 600.0 | nM | 6.22 | Inverse agonist activity at human CB1 receptor by [35S]GTPgammaS incorporation a... | 19520572 |
| Cannabinoid receptor 2 | Ki | = | 3919.0 | nM | 5.41 | Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells... | 19520572 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19520572 | 10.1016/j.bmcl.2009.05.114 | Cannabinoid receptor 1 | 4 |
| 19520572 | 10.1016/j.bmcl.2009.05.114 | Cannabinoid receptor 2 | 1 |
| 19520572 | 10.1016/j.bmcl.2009.05.114 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine