Compound Detail
CHEMBL555079
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Basic Information
| ChEMBL ID | CHEMBL555079 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PTRXYNKPFSGYQT-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1195643 |
| Active Moiety | CHEMBL1195643 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
322.3
MW (Da)
0.90
ALogP
8
HBA
4
HBD
158.7
PSA (Ų)
0.46
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.54 | 6.54 | 290.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 290.0 | nM | 6.54 | In vitro inhibition of binding of [3H]AMPA towards AMPA receptor in rat | 10021939 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10021939 | 10.1016/s0960-894x(98)00720-3 | Glutamate receptor ionotropic, AMPA | 1 |
| 10021939 | 10.1016/s0960-894x(98)00720-3 | Glutamate receptor ionotropic, NMDA 1 | 1 |
| 10021939 | 10.1016/s0960-894x(98)00720-3 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine