Assay Detail
Binding
CHEMBL644174
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In vitro inhibition of binding of [3H]AMPA towards AMPA receptor in rat
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 6.21 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315547 | — | — | 1 | 7.17 |
| CHEMBL310892 | — | — | 1 | 7.16 |
| CHEMBL85900 | — | — | 1 | 7.10 |
| CHEMBL538017 | — | — | 1 | 6.92 |
| CHEMBL543364 | — | — | 1 | 6.80 |
| CHEMBL82626 | — | — | 1 | 6.77 |
| CHEMBL86904 | — | — | 1 | 6.70 |
| CHEMBL82005 | — | — | 1 | 6.70 |
| CHEMBL84775 | — | — | 1 | 6.54 |
| CHEMBL555079 | — | — | 1 | 6.54 |
| CHEMBL85203 | — | — | 1 | 6.51 |
| CHEMBL539019 | — | — | 1 | 6.51 |
| CHEMBL553895 | — | — | 1 | 6.47 |
| CHEMBL84990 | — | — | 1 | 6.42 |
| CHEMBL553775 | — | — | 1 | 6.42 |
| CHEMBL543367 | — | — | 1 | 6.42 |
| CHEMBL82513 | — | — | 1 | 6.27 |
| CHEMBL85211 | — | — | 1 | 6.21 |
| CHEMBL82071 | — | — | 1 | 6.19 |
| CHEMBL554460 | — | — | 1 | 5.92 |
| CHEMBL82963 | — | — | 1 | 5.92 |
| CHEMBL83923 | — | — | 1 | 5.89 |
| CHEMBL313910 | — | — | 1 | 5.89 |
| CHEMBL84778 | — | — | 1 | 5.85 |
| CHEMBL543132 | — | — | 1 | 5.72 |
| CHEMBL83474 | — | — | 1 | 5.70 |
| CHEMBL87416 | — | — | 1 | 5.70 |
| CHEMBL83198 | — | — | 1 | 5.62 |
| CHEMBL86313 | — | — | 1 | 5.52 |
| CHEMBL84987 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315547 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL310892 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL85900 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL538017 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL543364 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL82626 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL86904 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL82005 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL84775 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL555079 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL85203 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL539019 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL553895 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL543367 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL553775 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL84990 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL82513 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL85211 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL82071 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL554460 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL82963 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL83923 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL313910 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL84778 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL543132 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL83474 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL87416 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL83198 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL86313 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL84987 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL554613 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL84432 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL543131 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL83360 | — | IC50 | = | 105000.0 | nM | - |