Compound Detail
CHEMBL553775
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL553775 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MJZIYDSQSYBRHG-UHFFFAOYSA-N |
| Parent Compound | CHEMBL1195053 |
| Active Moiety | CHEMBL1195053 |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
308.2
MW (Da)
0.51
ALogP
8
HBA
4
HBD
158.7
PSA (Ų)
0.34
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.42
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.42 | 6.42 | 380.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.72 | 4.72 | 19000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 380.0 | nM | 6.42 | In vitro inhibition of binding of [3H]AMPA towards AMPA receptor in rat | 10021939 |
| Glutamate NMDA receptor | IC50 | = | 19000.0 | nM | 4.72 | In vitro inhibition of binding of [3H]MDL-105519 towards glycine binding site of... | 10021939 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10021939 | 10.1016/s0960-894x(98)00720-3 | Glutamate receptor ionotropic, AMPA | 1 |
| 10021939 | 10.1016/s0960-894x(98)00720-3 | Glutamate NMDA receptor | 1 |
| 10021939 | 10.1016/s0960-894x(98)00720-3 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine