Assay Detail
Binding
CHEMBL749210
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In vitro inhibition of binding of [3H]MDL-105519 towards glycine binding site of NMDA receptor in rat
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
N-phosphonoalkyl-5-aminomethylquinoxaline-2,3-diones: in vivo active AMPA and NMDA(glycine) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.41 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86313 | — | — | 1 | 8.22 |
| CHEMBL82963 | — | — | 1 | 8.22 |
| CHEMBL82626 | — | — | 1 | 7.50 |
| CHEMBL543131 | — | — | 1 | 7.40 |
| CHEMBL443011 | — | — | 1 | 7.35 |
| CHEMBL83198 | — | — | 1 | 7.00 |
| CHEMBL87710 | — | — | 1 | 6.96 |
| CHEMBL313510 | — | — | 1 | 6.92 |
| CHEMBL84432 | — | — | 1 | 6.92 |
| CHEMBL83474 | — | — | 1 | 6.52 |
| CHEMBL87416 | — | — | 1 | 6.51 |
| CHEMBL84778 | — | — | 1 | 6.43 |
| CHEMBL313910 | — | — | 1 | 6.38 |
| CHEMBL85567 | — | — | 1 | 6.30 |
| CHEMBL82513 | — | — | 1 | 6.23 |
| CHEMBL543364 | — | — | 1 | 6.12 |
| CHEMBL84775 | — | — | 1 | 6.00 |
| CHEMBL543367 | — | — | 1 | 5.89 |
| CHEMBL539019 | — | — | 1 | 5.77 |
| CHEMBL554613 | — | — | 1 | 5.66 |
| CHEMBL83360 | — | — | 1 | 5.48 |
| CHEMBL310892 | — | — | 1 | 5.41 |
| CHEMBL315547 | — | — | 1 | 5.40 |
| CHEMBL85211 | — | — | 1 | 5.05 |
| CHEMBL553775 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86313 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL82963 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL82626 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL543131 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL443011 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL83198 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL87710 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL313510 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL84432 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL83474 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL87416 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL84778 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL313910 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL85567 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL82513 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL543364 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL84775 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL543367 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL539019 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL554613 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL83360 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL310892 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL315547 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL85211 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL553775 | — | IC50 | = | 19000.0 | nM | 4.72 |