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Compound Detail

CHEMBL5556781

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C=CCc1ccccc1OC[C@@H](O)CNCCCc1cn(CCCc2ccc(OC[C@@H](O)CNC(C)C)cc2)nn1

Basic Information

ChEMBL ID CHEMBL5556781
Phase Preclinical
Structure Type MOL
InChI Key SQIGEIFJPCDYCC-KYJUHHDHSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

565.8
MW (Da)
3.34
ALogP
9
HBA
4
HBD
113.7
PSA (Ų)
0.11
QED
1
Ro5 Violations
21
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H47N5O4
MW 565.76
Aromatic Rings 3
Heavy Atoms 41
NP-Likeness -0.84

Activity Summary

IC50 1 meas. best 8.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
IC50 8.33 8.33 4.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
38952152 10.1021/acs.jmedchem.4c00578 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine