Compound Detail
CHEMBL5556812
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Basic Information
| ChEMBL ID | CHEMBL5556812 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BHIHRRBEEJSNEX-ACAGNQJTSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
3.36
ALogP
4
HBA
3
HBD
86.9
PSA (Ų)
0.63
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase tousled-like 2 CHEMBL5404 | IC50 | 6.75 | 6.75 | 180.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase tousled-like 2 | IC50 | = | 180.0 | nM | 6.75 | Inhibition of human TLK2 preincubated for 20 mins followed by 33P-ATP addition a... | 38636130 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38636130 | 10.1016/j.ejmech.2024.116357 | Serine/threonine-protein kinase tousled-like 2 | 1 |
| 38636130 | 10.1016/j.ejmech.2024.116357 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 38636130 | 10.1016/j.ejmech.2024.116357 | NT-3 growth factor receptor | 1 |
| 38636130 | 10.1016/j.ejmech.2024.116357 | Serine/threonine-protein kinase tousled-like 1 | 1 |
Data from ChEMBL 36 via Core Engine