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Compound Detail

CHEMBL5561211

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CC[C@@]1(OC(=O)CCC(=O)NCCOCCOCC(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)N[C@@H](CCCCNc2ccc([N+](=O)[O-])cc2[N+](=O)[O-])C(N)=O)C(c2ccccc2)c2ccccc2)C(=O)OCc2c1cc1n(c2=O)Cc2cc3ccccc3nc2-1

Basic Information

ChEMBL ID CHEMBL5561211
Phase Preclinical
Structure Type MOL
InChI Key BGKLLVHJICGNKF-QNFZNJDBSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

2309.7
MW (Da)

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C120H149N25O23
MW 2309.66

Activity Summary

IC50 1 meas. best 4.93

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
A20
CHEMBL613850
IC50 4.93 4.93 11800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
A20 IC50 = 11800.0 nM 4.93 Cytostatic activity against mouse A20 cells after 24 hrs by CCK-8 assay 38278140

Literature References

PubMed DOI Target Context # Activities
38278140 10.1021/acs.jmedchem.3c02232 ADMET 5
38278140 10.1021/acs.jmedchem.3c02232 A20 1

Data from ChEMBL 36 via Core Engine