Compound Detail
CHEMBL5562340
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Basic Information
| ChEMBL ID | CHEMBL5562340 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZBWHBKUMYLPCMF-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
416.5
MW (Da)
4.38
ALogP
5
HBA
1
HBD
59.4
PSA (Ų)
0.69
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Kd 1 meas. best 7.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase NSD2 CHEMBL3108645 | Kd | 7.9 | 7.9 | 12.6 | 1 |
| Histone-lysine N-methyltransferase NSD2 CHEMBL3108645 | IC50 | 7.7 | 7.7 | 19.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone-lysine N-methyltransferase NSD2 | Kd | = | 12.59 | nM | 7.9 | Binding affinity to human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 re... | 38748070 |
| Histone-lysine N-methyltransferase NSD2 | IC50 | = | 19.95 | nM | 7.7 | Inhibition of human C-terminal his tagged NSD2 PWWP1 domain (208 to 358 residues... | 38748070 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38748070 | 10.1021/acs.jmedchem.4c00215 | Histone-lysine N-methyltransferase NSD2 | 2 |
| 38748070 | 10.1021/acs.jmedchem.4c00215 | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine