Compound Detail
CHEMBL5564292
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Basic Information
| ChEMBL ID | CHEMBL5564292 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QZTYHEBMBDXRNC-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
329.8
MW (Da)
4.37
ALogP
4
HBA
1
HBD
37.4
PSA (Ų)
0.91
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 7.81 | 7.8 | 15.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 15.4 | nM | 7.81 | Inhibition of PIM1 (unknown origin) | 38164076 |
| Serine/threonine-protein kinase pim-1 | IC50 | = | 16.4 | nM | 7.79 | Inhibition of full length PIM1 (unknown origin) expressed in Escherichia coli BL... | 38071792 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38164076 | 10.1021/acs.jmedchem.3c01802 | Serine/threonine-protein kinase pim-1 | 1 |
| 38071792 | 10.1016/j.ejmech.2023.116016 | Serine/threonine-protein kinase pim-1 | 1 |
Data from ChEMBL 36 via Core Engine