Assay Detail
Binding
CHEMBL5535186
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Inhibition of PIM1 (unknown origin)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Comprehensive Insights that Targeting PIM for Cancer Therapy: Prospects and Obstacles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.08 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5595384 | — | — | 1 | 9.62 |
| CHEMBL5570349 | — | — | 1 | 9.05 |
| CHEMBL5595879 | — | — | 1 | 8.77 |
| CHEMBL4467168 | DAPOLSERTIB | 2.0 | 1 | 8.70 |
| CHEMBL5573588 | — | — | 1 | 8.52 |
| CHEMBL3975308 | NUVISERTIB | 2.0 | 1 | 8.30 |
| CHEMBL3651966 | LGH-447 | 1.0 | 1 | 8.24 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 8.15 |
| CHEMBL5564292 | — | — | 1 | 7.81 |
| CHEMBL4878958 | — | — | 1 | 7.65 |
| CHEMBL5199618 | — | — | 1 | 7.45 |
| CHEMBL5205827 | — | — | 1 | 7.24 |
| CHEMBL5204548 | — | — | 1 | 7.09 |
| CHEMBL4869696 | — | — | 1 | 6.55 |
| CHEMBL1398474 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5595384 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL5570349 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL5595879 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4467168 | DAPOLSERTIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5573588 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3975308 | NUVISERTIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3651966 | LGH-447 | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL5564292 | — | IC50 | = | 15.4 | nM | 7.81 |
| CHEMBL4878958 | — | IC50 | = | 22.27 | nM | 7.65 |
| CHEMBL5199618 | — | IC50 | = | 35.13 | nM | 7.45 |
| CHEMBL5205827 | — | IC50 | = | 57.34 | nM | 7.24 |
| CHEMBL5204548 | — | IC50 | = | 81.49 | nM | 7.09 |
| CHEMBL4869696 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL1398474 | — | IC50 | = | 1.28 | nM | - |