Compound Detail
CHEMBL4467168
DAPOLSERTIB 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL4467168 |
| Name | DAPOLSERTIB |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | UOUBCIJIWDLRGM-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
6
Known Names
1
Indications
Molecular Properties
446.1
MW (Da)
4.52
ALogP
5
HBA
1
HBD
73.0
PSA (Ų)
0.56
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Neoplasms
Activity Summary
IC50 3 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Serine/threonine-protein kinase pim-3 CHEMBL5407 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of PIM1 (unknown origin) | 38164076 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of PIM2 (unknown origin) | 38164076 |
| Serine/threonine-protein kinase pim-3 | IC50 | = | 3.0 | nM | 8.52 | Inhibition of PIM3 (unknown origin) | 38164076 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31207462 | 10.1016/j.ejmech.2019.06.002 | MV4-11 | 3 |
| 38164076 | 10.1021/acs.jmedchem.3c01802 | Serine/threonine-protein kinase pim-1 | 1 |
| 38164076 | 10.1021/acs.jmedchem.3c01802 | Serine/threonine-protein kinase pim-2 | 1 |
| 38164076 | 10.1021/acs.jmedchem.3c01802 | Serine/threonine-protein kinase pim-3 | 1 |
Data from ChEMBL 36 via Core Engine