Assay Detail
Binding
CHEMBL5535187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM2 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Comprehensive Insights that Targeting PIM for Cancer Therapy: Prospects and Obstacles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.72 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4467168 | DAPOLSERTIB | 2.0 | 1 | 8.70 |
| CHEMBL5573588 | — | — | 1 | 8.30 |
| CHEMBL5595384 | — | — | 1 | 7.52 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 7.44 |
| CHEMBL3975308 | NUVISERTIB | 2.0 | 1 | 6.62 |
| CHEMBL3651966 | LGH-447 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4467168 | DAPOLSERTIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL5573588 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5595384 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 36.3 | nM | 7.44 |
| CHEMBL3975308 | NUVISERTIB | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL3651966 | LGH-447 | IC50 | = | 18.0 | nM | - |