Compound Detail
CHEMBL5565301
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Cc1cn(-c2cc(C(=O)Nc3ccc(C)c(NC(=O)c4cc(C)on4)c3)cc(C(F)(F)F)c2)cn1
Basic Information
| ChEMBL ID | CHEMBL5565301 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KQZCTQLSBJBYEA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
483.4
MW (Da)
5.31
ALogP
6
HBA
2
HBD
102.0
PSA (Ų)
0.40
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 7.0 | 7.0 | 101.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 101.0 | nM | 7.0 | Inhibition of human CSF1R using pEY as substrate incubated for 40 mins in presen... | 38401188 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38401188 | 10.1016/j.ejmech.2024.116253 | Macrophage colony-stimulating factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine