Compound Detail
CHEMBL5565890
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5565890 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XMCIAZOXXWMQPU-ZDUSSCGKSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
417.4
MW (Da)
0.84
ALogP
8
HBA
3
HBD
158.1
PSA (Ų)
0.55
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.22
IC50 1 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Egl nine homolog 1 CHEMBL5697 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 5.22 | 5.22 | 6000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Egl nine homolog 1 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of PHD2 (unknown origin) preincubated for 30 mins followed by substra... | 38189253 |
| Unchecked | EC50 | = | 6000.0 | nM | 5.22 | Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA | 38189253 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38189253 | 10.1021/acs.jmedchem.3c01932 | ADMET | 2 |
| 38189253 | 10.1021/acs.jmedchem.3c01932 | Egl nine homolog 1 | 1 |
| 38189253 | 10.1021/acs.jmedchem.3c01932 | Unchecked | 1 |
| 38189253 | 10.1021/acs.jmedchem.3c01932 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine