Compound Detail
CHEMBL5566972
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Basic Information
| ChEMBL ID | CHEMBL5566972 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJYHWJQROXMRFQ-INIZCTEOSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
342.2
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome subunit beta type-9 CHEMBL1944495 | IC50 | 8.3 | 8.3 | 5.0 | 1 |
| Proteasome subunit beta type-8 CHEMBL5620 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 6.52 | 6.52 | 302.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome subunit beta type-9 | IC50 | = | 5.0 | nM | 8.3 | Inhibition of human LMP2 beta-1i subunit using Ac-PAL-AMC as substrate preincuba... | 38906067 |
| Proteasome subunit beta type-8 | IC50 | = | 8.0 | nM | 8.1 | Inhibition of human LMP7 beta -5i subunit using Ac-ANW-AMC as substrate preincub... | 38906067 |
| Proteasome Macropain subunit MB1 | IC50 | = | 302.0 | nM | 6.52 | Inhibition of human 20S proteosome beta5c subunit using Ac-WLA-AMC as substrate ... | 38906067 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38906067 | 10.1016/j.bmc.2024.117790 | Proteasome subunit beta type-8 | 1 |
| 38906067 | 10.1016/j.bmc.2024.117790 | Proteasome subunit beta type-9 | 1 |
| 38906067 | 10.1016/j.bmc.2024.117790 | Proteasome Macropain subunit MB1 | 1 |
| 38906067 | 10.1016/j.bmc.2024.117790 | Unchecked | 1 |
| 38906067 | 10.1016/j.bmc.2024.117790 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine