Compound Detail
CHEMBL5567374
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Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCOc2ccc(N(CC(F)(F)F)S(=O)(=O)C3CC4OC3C(c3ccc(-n5ccnc5)cc3)=C4c3ccc(O)cc3)cc2)C(C)(C)C)cc1
Basic Information
| ChEMBL ID | CHEMBL5567374 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PLAVXXXKWALXPD-LVBUJRILSA-N |
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
11
Publications
0
Known Names
Molecular Properties
1124.3
MW (Da)
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 7.12
Ki 1 meas. best 6.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MCF7 CHEMBL387 | IC50 | 7.12 | 6.385 | 75.0 | 4 |
| Estrogen receptor CHEMBL206 | Ki | 6.6 | 6.6 | 250.0 | 1 |
| Aromatase CHEMBL1978 | IC50 | 5.34 | 5.34 | 4600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MCF7 | IC50 | = | 75.0 | nM | 7.12 | Antiproliferative activity against human resistant MCF7 cells harboring EGFR ass... | 38809993 |
| Estrogen receptor | Ki | = | 250.0 | nM | 6.6 | Binding affinity to human ERalpha assessed as inhibition constant incubated unde... | 38809993 |
| MCF7 | IC50 | = | 310.0 | nM | 6.51 | Antiproliferative activity against human resistant MCF7 cells harboring ERalpha ... | 38809993 |
| MCF7 | IC50 | = | 540.0 | nM | 6.27 | Anti-proliferative activity against ERalpha positive human MCF7 cells incubated ... | 38809993 |
| MCF7 | IC50 | = | 2300.0 | nM | 5.64 | Antiproliferative activity against human resistant MCF7 cells harboring ERalpha ... | 38809993 |
| Aromatase | IC50 | = | 4600.0 | nM | 5.34 | Inhibition of recombinant human aromatase using ARO substrate/NADP+ mixture by f... | 38809993 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38809993 | 10.1021/acs.jmedchem.4c00196 | Unchecked | 14 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | MCF7 | 9 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | ADMET | 5 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | von Hippel-Lindau disease tumor suppressor/Aromatase | 4 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | Estrogen receptor | 3 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | von Hippel-Lindau disease tumor suppressor/Estrogen receptor | 3 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | Estrogen receptor beta | 2 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | MCF-10A | 1 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | Aromatase | 1 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | von Hippel-Lindau disease tumor suppressor-Estrogen receptor beta | 1 |
| 38809993 | 10.1021/acs.jmedchem.4c00196 | von Hippel-Lindau disease tumor suppressor/Androgen receptor | 1 |
Data from ChEMBL 36 via Core Engine