Compound Detail
CHEMBL5568849
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1cc(C(=O)Nc2cc(C(=O)Nc3cc(NC4CCN(C)CC4)cc(C(F)(F)F)c3)ccc2C)no1
Basic Information
| ChEMBL ID | CHEMBL5568849 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SBTHXQTVTXRLMX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
515.5
MW (Da)
5.32
ALogP
6
HBA
3
HBD
99.5
PSA (Ų)
0.41
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor CHEMBL1844 | IC50 | 6.4 | 6.4 | 399.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage colony-stimulating factor 1 receptor | IC50 | = | 399.0 | nM | 6.4 | Inhibition of human CSF1R using pEY as substrate incubated for 40 mins in presen... | 38401188 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38401188 | 10.1016/j.ejmech.2024.116253 | Macrophage colony-stimulating factor 1 receptor | 2 |
| 38401188 | 10.1016/j.ejmech.2024.116253 | RAW264.7 | 1 |
Data from ChEMBL 36 via Core Engine