Compound Detail
CHEMBL5570505
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Basic Information
| ChEMBL ID | CHEMBL5570505 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XXQKGHXWZVWLPV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
484.6
MW (Da)
5.31
ALogP
4
HBA
1
HBD
67.9
PSA (Ų)
0.47
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bile acid receptor CHEMBL2047 | IC50 | 5.37 | 5.37 | 4270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bile acid receptor | IC50 | = | 4270.0 | nM | 5.37 | Antagonist activity against human FXR transfected in HEK293T cells co-transfecte... | 38043493 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38043493 | 10.1016/j.ejmech.2023.115992 | Mus musculus | 40 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | Unchecked | 8 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | HepG2 | 3 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | Bile acid receptor | 2 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | L02 | 1 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | Peroxisome proliferator-activated receptor alpha | 1 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | Peroxisome proliferator-activated receptor delta | 1 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | Peroxisome proliferator-activated receptor gamma | 1 |
| 38043493 | 10.1016/j.ejmech.2023.115992 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine