Compound Detail
CHEMBL5571220
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Basic Information
| ChEMBL ID | CHEMBL5571220 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KPDINFUQWYDWPT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
1
PK Parameters
5
Publications
0
Known Names
Molecular Properties
349.4
MW (Da)
1.45
ALogP
7
HBA
0
HBD
63.0
PSA (Ų)
0.69
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 10.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 CHEMBL3085 | EC50 | 10.7 | 10.7 | 0.0 | 1 |
| Excitatory amino acid transporter 2 CHEMBL4973 | EC50 | 9.0 | 9.0 | 1.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 1.038 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 | EC50 | = | 0.02 | nM | 10.7 | Positive allosteric modulation of EAAT1 (unknown origin) transfected in African ... | 38626917 |
| Excitatory amino acid transporter 2 | EC50 | = | 1.0 | nM | 9.0 | Positive allosteric modulation of EAAT2 (unknown origin) transfected in African ... | 38626917 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38626917 | 10.1021/acs.jmedchem.3c01909 | Excitatory amino acid transporter 1 | 1 |
| 38626917 | 10.1021/acs.jmedchem.3c01909 | Excitatory amino acid transporter 2 | 1 |
| 38626917 | 10.1021/acs.jmedchem.3c01909 | Excitatory amino acid transporter 3 | 1 |
| 38626917 | 10.1021/acs.jmedchem.3c01909 | No relevant target | 1 |
| 38626917 | 10.1021/acs.jmedchem.3c01909 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine