Compound Detail
CHEMBL5572569
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Basic Information
| ChEMBL ID | CHEMBL5572569 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZFZJIPVEQXFDIS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
400.4
MW (Da)
4.21
ALogP
4
HBA
2
HBD
83.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 4 CHEMBL3524 | IC50 | 6.16 | 6.16 | 690.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.84 | 4.84 | 14500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 4 | IC50 | = | 690.0 | nM | 6.16 | Inhibition of human recombinant TEV-8His-tagged HDAC4 (648 to 1057 residues) exp... | 37979441 |
| Unchecked | IC50 | = | 14500.0 | nM | 4.84 | Inhibition of Class IIa/8 HDAC in human THP-1 cells preincubated for 18 hrs foll... | 37979441 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37979441 | 10.1016/j.ejmech.2023.115907 | Unchecked | 7 |
| 37979441 | 10.1016/j.ejmech.2023.115907 | THP-1 | 2 |
| 37979441 | 10.1016/j.ejmech.2023.115907 | Histone deacetylase 4 | 1 |
| 37979441 | 10.1016/j.ejmech.2023.115907 | Histone deacetylase 2 | 1 |
| 37979441 | 10.1016/j.ejmech.2023.115907 | Histone deacetylase 6 | 1 |
| 37979441 | 10.1016/j.ejmech.2023.115907 | Histone deacetylase 8 | 1 |
Data from ChEMBL 36 via Core Engine