Compound Detail
CHEMBL5573416
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5573416 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JWNAFJSECNVHJU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
348.4
MW (Da)
2.16
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.90
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 CHEMBL3085 | EC50 | 8.28 | 8.28 | 5.3 | 1 |
| Excitatory amino acid transporter 2 CHEMBL4973 | EC50 | 8.21 | 8.21 | 6.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Excitatory amino acid transporter 1 | EC50 | = | 5.3 | nM | 8.28 | Positive allosteric modulation of EAAT1 (unknown origin) transfected in African ... | 38626917 |
| Excitatory amino acid transporter 2 | EC50 | = | 6.1 | nM | 8.21 | Positive allosteric modulation of EAAT2 (unknown origin) transfected in African ... | 38626917 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38626917 | 10.1021/acs.jmedchem.3c01909 | Excitatory amino acid transporter 1 | 1 |
| 38626917 | 10.1021/acs.jmedchem.3c01909 | Excitatory amino acid transporter 2 | 1 |
| 38626917 | 10.1021/acs.jmedchem.3c01909 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine