Compound Detail
CHEMBL5574486
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5574486 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RLJNIQLDFASOAA-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
321.3
MW (Da)
4.49
ALogP
2
HBA
1
HBD
41.6
PSA (Ų)
0.60
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 6.92 | 6.37 | 120.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 120.0 | nM | 6.92 | Inhibition of TRKA (unknown origin) using TK peptide as substrate incubated for ... | 38029466 |
| High affinity nerve growth factor receptor | IC50 | = | 1520.0 | nM | 5.82 | Inhibition of TRKA (unknown origin) G595R mutant using TK peptide as substrate i... | 38029466 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38029466 | 10.1016/j.ejmech.2023.115953 | High affinity nerve growth factor receptor | 2 |
Data from ChEMBL 36 via Core Engine