Compound Detail
CHEMBL5575032
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5575032 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHNFTGKRRUDUST-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
237.3
MW (Da)
2.50
ALogP
3
HBA
1
HBD
44.5
PSA (Ų)
0.87
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.38
Ki 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 8.38 | 8.38 | 4.2 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 8.0 | 8.0 | 9.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | EC50 | = | 4.2 | nM | 8.38 | Agonist activity at human 5-HT2A receptor expressed in HEK293 cells assessed as ... | 38593423 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 9.9 | nM | 8.0 | Displacement of [3H]LSD from human 5-HT2A receptor expressed in HEK293 cell memb... | 38593423 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38593423 | 10.1021/acs.jmedchem.3c01961 | 5-hydroxytryptamine receptor 2A | 2 |
Data from ChEMBL 36 via Core Engine