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Compound Detail

CHEMBL5579662

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CCn1c(=O)/c(=C2/Sc3ccccc3N2C)s/c1=C\c1cccc[n+]1C.[Cl-]

Basic Information

ChEMBL ID CHEMBL5579662
Phase Preclinical
Structure Type MOL
InChI Key KEQDCNWQIQWINZ-GQQUDWLYSA-M
Parent Compound CHEMBL6069973
Active Moiety CHEMBL6069973
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

382.5
MW (Da)
1.89
ALogP
5
HBA
0
HBD
29.1
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H20ClN3OS2
MW 417.99
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -0.93

Activity Summary

IC50 1 meas. best 5.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 5.5 5.5 3200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked IC50 = 3200.0 nM 5.5 Inhibition of Hsp70 (unknown origin) by ATPase activity 37839344

Literature References

PubMed DOI Target Context # Activities
37839344 10.1016/j.ejmech.2023.115859 Unchecked 1

Data from ChEMBL 36 via Core Engine