Compound Detail
CHEMBL5596348
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COc1cc(-c2ccn3nc(NC(=O)NCCOc4ccccc4)c(-c4cnn(C)c4)c3n2)cnc1OC
Basic Information
| ChEMBL ID | CHEMBL5596348 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IRLZQIIOZUOUHZ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
514.5
MW (Da)
3.41
ALogP
10
HBA
2
HBD
129.7
PSA (Ų)
0.29
QED
1
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 5.12 | 5.12 | 7500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 7500.0 | nM | 5.12 | Inhibition of PI3K alpha (unknown origin) using PI3:PS as substrate incubated fo... | 39163191 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39163191 | 10.1021/acs.jmedchem.4c00817 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 39163191 | 10.1021/acs.jmedchem.4c00817 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine