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Compound Detail

CHEMBL559931

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CC1(C(=O)O[C@H]2C[N+]3(CCCOc4ccccc4)CCC2CC3)c2ccccc2-c2ccccc21.[Br-]

Basic Information

ChEMBL ID CHEMBL559931
Phase Preclinical
Structure Type MOL
InChI Key KVAQGLGKAIWEJG-NTHLUGJQSA-M
Parent Compound CHEMBL1197117
Active Moiety CHEMBL1197117
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

468.6
MW (Da)
5.59
ALogP
3
HBA
0
HBD
35.5
PSA (Ų)
0.26
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H34BrNO3
MW 548.52
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness 0.32

Activity Summary

IC50 3 meas. best 9.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
IC50 9.02 9.02 1.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
IC50 8.9 8.9 1.3 1
Muscarinic acetylcholine receptor M2
CHEMBL211
IC50 8.68 8.68 2.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19653626 10.1021/jm900132z Muscarinic acetylcholine receptor M1 1
19653626 10.1021/jm900132z Muscarinic acetylcholine receptor M2 1
19653626 10.1021/jm900132z Muscarinic acetylcholine receptor M3 1
19653626 10.1021/jm900132z Mus musculus 1

Data from ChEMBL 36 via Core Engine