Compound Detail
CHEMBL560462
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL560462 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KXSRKQVGOXLZPF-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
470.6
MW (Da)
5.48
ALogP
4
HBA
1
HBD
75.7
PSA (Ų)
0.40
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.59
EC50 1 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL218 | EC50 | 6.7 | 6.7 | 200.0 | 1 |
| Cannabinoid receptor 1 CHEMBL218 | Ki | 6.59 | 6.59 | 256.0 | 1 |
| Cannabinoid receptor 2 CHEMBL253 | Ki | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | EC50 | = | 200.0 | nM | 6.7 | Inverse agonist activity at human CB1 receptor by [35S]GTPgammaS incorporation a... | 19520572 |
| Cannabinoid receptor 1 | Ki | = | 256.0 | nM | 6.59 | Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells... | 19520572 |
| Cannabinoid receptor 2 | Ki | = | 10000.0 | nM | 5.0 | Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells... | 19520572 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19520572 | 10.1016/j.bmcl.2009.05.114 | Cannabinoid receptor 1 | 4 |
| 19520572 | 10.1016/j.bmcl.2009.05.114 | Cannabinoid receptor 2 | 1 |
| 19520572 | 10.1016/j.bmcl.2009.05.114 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine