Compound Detail
CHEMBL5612410
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Basic Information
| ChEMBL ID | CHEMBL5612410 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | APGWGVCWLYVCSY-UHFFFAOYSA-N |
3
Targets
5
Activities
2
Assay Types
9
PK Parameters
4
Publications
0
Known Names
Molecular Properties
472.5
MW (Da)
3.73
ALogP
6
HBA
1
HBD
71.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.33
IC50 2 meas. best 6.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | Ki | 9.33 | 9.33 | 0.5 | 1 |
| Unchecked CHEMBL612545 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL1075228 | Ki | 8.89 | 8.89 | 1.3 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 6.78 | 6.78 | 168.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 21.6 | uM.hr | Rattus norvegicus |
| AUC | 1.6 | uM.hr | Rattus norvegicus |
| CL | 22.1 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 1600.0 | nM | Rattus norvegicus |
| Fu | 0.021 | - | Homo sapiens |
| Fu | 0.044 | - | Rattus norvegicus |
| MRT | 8.6 | hr | Rattus norvegicus |
| T1/2 | 7.52 | hr | Rattus norvegicus |
| Tmax | 4.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | Ki | = | 0.47 | nM | 9.33 | Displacement of [125I]MCH from human MCHR1 extracted from HEK293 cell membrane a... | 39053192 |
| Unchecked | Ki | = | 0.5 | nM | 9.3 | Radioligand Binding Assay: An in vitro binding assay was used to determine the c... | - |
| Melanin-concentrating hormone receptor 1 | Ki | = | 1.29 | nM | 8.89 | Displacement of [125I]MCH from rat MCHR1 extracted from HEK293 cell membrane ass... | 39053192 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 168.0 | nM | 6.78 | Antagonist activity at MCHR1 (unknown origin) using MCH peptide as substrate ass... | 39053192 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 39053192 | 10.1016/j.ejmech.2024.116686 | ADMET | 28 |
| 39053192 | 10.1016/j.ejmech.2024.116686 | Melanin-concentrating hormone receptor 1 | 3 |
| 39053192 | 10.1016/j.ejmech.2024.116686 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 39053192 | 10.1016/j.ejmech.2024.116686 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine