Compound Detail
CHEMBL561835
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Basic Information
| ChEMBL ID | CHEMBL561835 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MIPWAABDGPOHJQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
242.3
MW (Da)
2.65
ALogP
3
HBA
1
HBD
51.2
PSA (Ų)
0.90
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 6.68 | 6.68 | 210.0 | 1 |
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 6.25 | 6.25 | 560.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 210.0 | nM | 6.68 | Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on ... | 19469556 |
| Metabotropic glutamate receptor 4 | EC50 | = | 560.0 | nM | 6.25 | Activity at human mGluR4 receptor expressed in CHO cells assessed as effect on c... | 19469556 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19469556 | 10.1021/jm9005065 | Metabotropic glutamate receptor 4 | 6 |
Data from ChEMBL 36 via Core Engine