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Compound Detail

CHEMBL56249

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CCCCCCC(C)(C)c1cc2c(c(OP(=O)(OCC)OCC)c1)[C@@H]1CC(C)=CC[C@H]1C(C)(C)O2

Basic Information

ChEMBL ID CHEMBL56249
Phase Preclinical
Structure Type MOL
InChI Key XRKWHUJWNHCGIL-DNQXCXABSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

506.7
MW (Da)
9.11
ALogP
5
HBA
0
HBD
54.0
PSA (Ų)
0.16
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H47O5P
MW 506.66
Aromatic Rings 1
Heavy Atoms 35
NP-Likeness 1.23

Activity Summary

Ki 1 meas. best 6.36

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
Ki 6.36 6.36 441.7 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cannabinoid receptor 2 Ki = 441.7 nM 6.36 Binding affinity against human Cannabinoid receptor 2 by using radioligand ([3H]... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/0960-894X(95)00573-C Cannabinoid receptor 1 2
- 10.1016/0960-894X(95)00573-C Cannabinoid receptor 2 1
- 10.1016/0960-894X(95)00573-C Cannabinoid receptor 1

Data from ChEMBL 36 via Core Engine