Compound Detail
CHEMBL563887
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL563887 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VJOYACFUOINUHV-IBGZPJMESA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
335.4
MW (Da)
2.54
ALogP
4
HBA
1
HBD
49.8
PSA (Ų)
0.86
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 CHEMBL216 | IC50 | 9.59 | 9.59 | 0.3 | 1 |
| Muscarinic acetylcholine receptor M3 CHEMBL245 | IC50 | 9.04 | 9.04 | 0.9 | 1 |
| Muscarinic acetylcholine receptor M2 CHEMBL211 | IC50 | 8.94 | 8.94 | 1.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | IC50 | = | 0.26 | nM | 9.59 | Displacement of [3H]NMS from human muscarinic M1 receptor expressed in CHOK1 cel... | 19653626 |
| Muscarinic acetylcholine receptor M3 | IC50 | = | 0.92 | nM | 9.04 | Displacement of [3H]NMS from human muscarinic M3 receptor expressed in CHOK1 cel... | 19653626 |
| Muscarinic acetylcholine receptor M2 | IC50 | = | 1.14 | nM | 8.94 | Displacement of [3H]NMS from human muscarinic M2 receptor expressed in CHOK1 cel... | 19653626 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19653626 | 10.1021/jm900132z | Muscarinic acetylcholine receptor M1 | 1 |
| 19653626 | 10.1021/jm900132z | Muscarinic acetylcholine receptor M2 | 1 |
| 19653626 | 10.1021/jm900132z | Muscarinic acetylcholine receptor M3 | 1 |
| 19653626 | 10.1021/jm900132z | Cavia porcellus | 1 |
| 19653626 | 10.1021/jm900132z | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine