Compound Detail
CHEMBL5639167
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Basic Information
| ChEMBL ID | CHEMBL5639167 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XUGSPLCFOQWFNQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
353.4
MW (Da)
2.02
ALogP
7
HBA
0
HBD
82.4
PSA (Ų)
0.67
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ryanodine receptor 2 CHEMBL4745 | EC50 | 7.58 | 7.58 | 26.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ryanodine receptor 2 | EC50 | = | 26.0 | nM | 7.58 | Inhibition of Full length wild type mouse RyR2 expressed in Flp-In-T-REx-293 cel... | 37922828 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37922828 | 10.1016/j.ejmech.2023.115910 | Ryanodine receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine