Ryanodine receptor 2 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt E9Q401. Use UniProt E9Q401 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt E9Q401 as the stable identity anchor, then attach disease evidence before program review.
Ryanodine receptor 2
Review this target as Ryanodine receptor 2, mapped to UniProt E9Q401. Sequence length is 4966 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ryanodine receptor 2 as ChEMBL target CHEMBL4745, mapped to UniProt E9Q401. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ryanodine receptor 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | E9Q401 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ryanodine receptor 2 |
| UniProt Accession | E9Q401 |
| Component Type | Protein |
| Sequence Length | 4966 aa |
Ryanodine receptor 2
Review this target as Ryanodine receptor 2, mapped to UniProt E9Q401. Sequence length is 4966 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5639852 | 7.89 | EC50 | 13.0 | Preclinical |
| CHEMBL5646836 | 7.66 | EC50 | 22.0 | Preclinical |
| CHEMBL5641800 | 7.64 | EC50 | 23.0 | Preclinical |
| CHEMBL5639167 | 7.58 | EC50 | 26.0 | Preclinical |
| CHEMBL5646884 | 7.55 | EC50 | 28.0 | Preclinical |
| CHEMBL5639480 | 7.47 | EC50 | 34.0 | Preclinical |
| CHEMBL5639313 | 7.32 | EC50 | 48.0 | Preclinical |
| CHEMBL5641840 | 7.3 | EC50 | 50.0 | Preclinical |
| CHEMBL5639295 | 7.23 | EC50 | 59.0 | Preclinical |
| CHEMBL5639861 | 7.02 | EC50 | 96.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 27 | 6.5 |