Compound Detail
CHEMBL5639295
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5639295 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KFPLLMPUAGAPHF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
359.3
MW (Da)
2.29
ALogP
6
HBA
0
HBD
73.1
PSA (Ų)
0.70
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ryanodine receptor 2 CHEMBL4745 | EC50 | 7.23 | 7.23 | 59.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ryanodine receptor 2 | EC50 | = | 59.0 | nM | 7.23 | Inhibition of Full length wild type mouse RyR2 expressed in Flp-In-T-REx-293 cel... | 37922828 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37922828 | 10.1016/j.ejmech.2023.115910 | Ryanodine receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine