Compound Detail
CHEMBL5639224
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5639224 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BNPIJURFJUPZGS-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
294.3
MW (Da)
2.63
ALogP
4
HBA
2
HBD
100.9
PSA (Ų)
0.53
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 8.4 | 8.4 | 4.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | IC50 | = | 4.0 | nM | 8.4 | Inhibition of GSK3beta (unknown origin) expressed in Sf9 cells incubated for 30 ... | 37573828 |
| Glycogen synthase kinase-3 beta | IC50 | = | 4.0 | nM | 8.4 | Inhibition of GST-tagged GSK3beta (unknown origin) | 37573828 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37573828 | 10.1016/j.ejmech.2023.115718 | Glycogen synthase kinase-3 beta | 2 |
Data from ChEMBL 36 via Core Engine