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Compound Detail

CHEMBL5641709

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CC(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C=O)CC(=O)O)C(C)C)C(C)C

Basic Information

ChEMBL ID CHEMBL5641709
Phase Preclinical
Structure Type MOL
InChI Key OOGHGBCRVSBUHH-GOYXDOSHSA-N
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
17
Publications
0
Known Names

Molecular Properties

543.6
MW (Da)
-2.09
ALogP
8
HBA
7
HBD
237.2
PSA (Ų)
0.10
QED
2
Ro5 Violations
16
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H37N5O10
MW 543.57
Aromatic Rings 0
Heavy Atoms 38
NP-Likeness 0.38

Activity Summary

Ki 3 meas. best 9.0
IC50 1 meas. best 7.32

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Caspase-3
CHEMBL2334
Ki 9.0 9.0 1.0 1
Caspase-2
CHEMBL4884
Ki 8.46 8.46 3.5 1
Caspase-7
CHEMBL3468
Ki 8.12 8.12 7.5 1
Caspase-2
CHEMBL4884
IC50 7.32 7.32 47.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.6019/CHEMBL5724709 HEK-293T 2
- 10.6019/CHEMBL5724709 U2OS 2
- 10.6019/CHEMBL5724709 Fibroblast 2
- 10.6019/CHEMBL5724796 Cyclin-dependent kinase 2 1
- 10.6019/CHEMBL5724796 Bromodomain-containing protein 4 1
- 10.6019/CHEMBL5724796 Transcription intermediary factor 1-alpha 1
- 10.6019/CHEMBL5724796 Peregrin 1
- 10.6019/CHEMBL5724796 Fibroblast growth factor receptor 2 1
- 10.6019/CHEMBL5724796 Tyrosine-protein kinase ABL1 1
- 10.6019/CHEMBL5724796 Aurora kinase A 1
- 10.6019/CHEMBL5724796 Mitogen-activated protein kinase 1 1
- 10.6019/CHEMBL5724796 Glycogen synthase kinase-3 beta 1
37453329 10.1016/j.ejmech.2023.115632 Caspase-2 1
- 10.6019/CHEMBL5724796 Casein kinase I isoform delta 1
- 10.6019/CHEMBL5723035 Caspase-7 1
- 10.6019/CHEMBL5723035 Caspase-3 1
- 10.6019/CHEMBL5723035 Caspase-2 1

Data from ChEMBL 36 via Core Engine