Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL565748

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
NC(=O)[C@@H]1CC=CC[C@@H]1C(=O)Nc1cc(Cl)cc(Cl)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL565748
Phase Preclinical
Structure Type MOL
InChI Key LGSJDCJXTBKTQK-NEPJUHHUSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

313.2
MW (Da)
3.00
ALogP
2
HBA
2
HBD
72.2
PSA (Ų)
0.84
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H14Cl2N2O2
MW 313.18
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -1.15

Activity Summary

EC50 1 meas. best 5.51

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Metabotropic glutamate receptor 4
CHEMBL2736
 EC50 5.51 5.51 3100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Metabotropic glutamate receptor 4 EC50 = 3100.0 nM 5.51 Allosteric modulator activity at human mGlu4 receptor expressed in CHO cells coe... 19640716

Literature References

PubMed DOI Target Context # Activities
19640716 10.1016/j.bmcl.2009.07.072 Metabotropic glutamate receptor 4 2

Data from ChEMBL 36 via Core Engine