Assay Detail
Functional
CHEMBL1044679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Allosteric modulator activity at human mGlu4 receptor expressed in CHO cells coexpressing Gqi5 assessed as effect on calcium flux
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 38 | 5.51 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL578988 | — | — | 1 | 6.13 |
| CHEMBL578358 | — | — | 1 | 6.02 |
| CHEMBL571063 | — | — | 1 | 5.70 |
| CHEMBL568240 | — | — | 1 | 5.70 |
| CHEMBL578129 | — | — | 1 | 5.57 |
| CHEMBL565748 | — | — | 1 | 5.51 |
| CHEMBL578793 | — | — | 1 | 5.48 |
| CHEMBL568252 | — | — | 1 | 5.02 |
| CHEMBL584413 | — | — | 1 | 5.00 |
| CHEMBL568440 | — | — | 1 | 5.00 |
| CHEMBL577918 | — | — | 1 | - |
| CHEMBL584412 | — | — | 1 | - |
| CHEMBL568226 | — | — | 1 | - |
| CHEMBL578381 | — | — | 1 | - |
| CHEMBL568227 | — | — | 1 | - |
| CHEMBL568029 | — | — | 1 | - |
| CHEMBL568441 | — | — | 1 | - |
| CHEMBL568452 | — | — | 1 | - |
| CHEMBL584609 | — | — | 1 | - |
| CHEMBL568253 | — | — | 1 | - |
| CHEMBL584209 | — | — | 1 | - |
| CHEMBL577474 | — | — | 1 | - |
| CHEMBL577542 | — | — | 1 | - |
| CHEMBL568453 | — | — | 1 | - |
| CHEMBL578589 | — | — | 1 | - |
| CHEMBL565947 | — | — | 1 | - |
| CHEMBL568225 | — | — | 1 | - |
| CHEMBL570602 | — | — | 1 | - |
| CHEMBL570838 | — | — | 1 | - |
| CHEMBL577252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL578988 | — | EC50 | = | 740.0 | nM | 6.13 |
| CHEMBL578358 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL568240 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL571063 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL578129 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL565748 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL578793 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL568252 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL584413 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL568440 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL568227 | — | EC50 | - | — | - | |
| CHEMBL568018 | — | EC50 | - | — | - | |
| CHEMBL568029 | — | EC50 | - | — | - | |
| CHEMBL568441 | — | EC50 | - | — | - | |
| CHEMBL568452 | — | EC50 | - | — | - | |
| CHEMBL584609 | — | EC50 | - | — | - | |
| CHEMBL568253 | — | EC50 | - | — | - | |
| CHEMBL577919 | — | EC50 | - | — | - | |
| CHEMBL571062 | — | EC50 | - | — | - | |
| CHEMBL584005 | — | EC50 | - | — | - | |
| CHEMBL577688 | — | EC50 | - | — | - | |
| CHEMBL568659 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL578593 | — | EC50 | - | — | - | |
| CHEMBL568228 | — | EC50 | - | — | - | |
| CHEMBL578381 | — | EC50 | - | — | - | |
| CHEMBL568226 | — | EC50 | - | — | - | |
| CHEMBL584412 | — | EC50 | - | — | - | |
| CHEMBL577918 | — | EC50 | - | — | - | |
| CHEMBL584209 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL577474 | — | EC50 | - | — | - | |
| CHEMBL577542 | — | EC50 | - | — | - | |
| CHEMBL568453 | — | EC50 | - | — | - | |
| CHEMBL578589 | — | EC50 | - | — | - | |
| CHEMBL565947 | — | EC50 | - | — | - | |
| CHEMBL568225 | — | EC50 | - | — | - | |
| CHEMBL570602 | — | EC50 | - | — | - | |
| CHEMBL570838 | — | EC50 | - | — | - | |
| CHEMBL577252 | — | EC50 | - | — | - |