Compound Detail
CHEMBL578988
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL578988 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSMUYYFJVFSVCA-NWDGAFQWSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
316.2
MW (Da)
3.82
ALogP
2
HBA
2
HBD
66.4
PSA (Ų)
0.89
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2736 | EC50 | 6.13 | 6.125 | 740.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 740.0 | nM | 6.13 | Allosteric modulator activity at human mGlu4 receptor expressed in CHO cells coe... | 19640716 |
| Metabotropic glutamate receptor 4 | EC50 | = | 750.0 | nM | 6.12 | Positive allosteric modulation of human mGlu4 receptor expressed in BHK cells as... | 21688779 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19640716 | 10.1016/j.bmcl.2009.07.072 | Metabotropic glutamate receptor 4 | 2 |
| 21688779 | 10.1021/jm200290z | Metabotropic glutamate receptor 4 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine