Compound Detail
CHEMBL566136
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Basic Information
| ChEMBL ID | CHEMBL566136 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FXPVOLWQNNGFHA-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
261.4
MW (Da)
3.48
ALogP
4
HBA
1
HBD
52.3
PSA (Ų)
0.86
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 6 CHEMBL4573 | IC50 | 6.12 | 6.12 | 750.0 | 1 |
| Replicase polyprotein 1ab CHEMBL4523582 | IC50 | 5.5 | 5.5 | 3190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 6 | IC50 | = | 750.0 | nM | 6.12 | Antagonist activity at human recombinant GluR6 expressed in HEK cells coexpressi... | 19819046 |
| Replicase polyprotein 1ab | IC50 | = | 3190.0 | nM | 5.5 | SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19819046 | 10.1016/j.ejmech.2009.09.025 | N2a | 2 |
| 19819046 | 10.1016/j.ejmech.2009.09.025 | ADMET | 2 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 19819046 | 10.1016/j.ejmech.2009.09.025 | Metabotropic glutamate receptor 5 | 1 |
| 19819046 | 10.1016/j.ejmech.2009.09.025 | Metabotropic glutamate receptor 6 | 1 |
| - | 10.6019/CHEMBL4495564 | Chymotrypsin | 1 |
| - | 10.6019/EOS300041 | Replicase polyprotein 1ab | 1 |
| - | 10.6019/EOS300044 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine