Compound Detail
CHEMBL567538
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Basic Information
| ChEMBL ID | CHEMBL567538 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UQYJVIVWKJSVEQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
2
Publications
0
Known Names
Molecular Properties
396.5
MW (Da)
2.70
ALogP
7
HBA
1
HBD
99.2
PSA (Ų)
0.63
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.56
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 6.56 | 6.56 | 275.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 17.0 | ug ml-1 | Homo sapiens |
| CL | 22.0 | ug ml-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 275.0 | nM | 6.56 | Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells as... | 19782566 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19782566 | 10.1016/j.bmcl.2009.09.016 | Liver microsomes | 2 |
| 19782566 | 10.1016/j.bmcl.2009.09.016 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine