Compound Detail
CHEMBL570907
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Basic Information
| ChEMBL ID | CHEMBL570907 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UKZQAPQRIDWZDG-UHFFFAOYSA-N |
2
Targets
7
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
4.44
ALogP
3
HBA
0
HBD
31.2
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 7.96
EC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 2 CHEMBL253 | Ki | 7.96 | 7.96 | 11.0 | 3 |
| Cannabinoid receptor 2 CHEMBL253 | EC50 | 7.7 | 7.7 | 20.0 | 1 |
| Cannabinoid receptor 1 CHEMBL218 | Ki | 6.88 | 6.88 | 131.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 2 | Ki | = | 11.0 | nM | 7.96 | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HE... | 19921781 |
| Cannabinoid receptor 2 | Ki | = | 10.96 | nM | 7.96 | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HE... | 19921781 |
| Cannabinoid receptor 2 | Ki | = | 11.0 | nM | 7.96 | Displacement of [3H]CP 55940 from human CB2 receptor in cell free system | 21183257 |
| Cannabinoid receptor 2 | EC50 | = | 20.0 | nM | 7.7 | Agonist activity at human recombinant CB2 receptor expressed in HEK293 cells coe... | 19921781 |
| Cannabinoid receptor 1 | Ki | = | 131.0 | nM | 6.88 | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CH... | 19921781 |
| Cannabinoid receptor 1 | Ki | = | 131.83 | nM | 6.88 | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in CH... | 19921781 |
| Cannabinoid receptor 1 | Ki | = | 131.0 | nM | 6.88 | Displacement of [3H]CP 55940 from human CB1 receptor in cell free system | 21183257 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19921781 | 10.1021/jm901214q | Cannabinoid receptor 2 | 4 |
| 19921781 | 10.1021/jm901214q | Cannabinoid receptor 1 | 2 |
| 19921781 | 10.1021/jm901214q | Unchecked | 1 |
| 21183257 | 10.1016/j.ejmech.2010.11.034 | Cannabinoid receptor 1 | 1 |
| 21183257 | 10.1016/j.ejmech.2010.11.034 | Cannabinoid receptor 2 | 1 |
| 21183257 | 10.1016/j.ejmech.2010.11.034 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine