Compound Detail
CHEMBL571453
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Basic Information
| ChEMBL ID | CHEMBL571453 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QJUCVRVRFWBVTF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
2
PK Parameters
3
Publications
0
Known Names
Molecular Properties
266.2
MW (Da)
3.35
ALogP
2
HBA
1
HBD
42.0
PSA (Ų)
0.91
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 CHEMBL2787 | EC50 | 5.75 | 5.75 | 1800.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Fu | 0.029 | - | Rattus norvegicus |
| Fu | 0.013 | - | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 4 | EC50 | = | 1800.0 | nM | 5.75 | Activity at rat mGluR4 receptor expressed in HEK293 cells assessed as effect on ... | 19469556 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19469556 | 10.1021/jm9005065 | Metabotropic glutamate receptor 4 | 6 |
| 19469556 | 10.1021/jm9005065 | Plasma | 2 |
| 19469556 | 10.1021/jm9005065 | Liver microsomes | 2 |
Data from ChEMBL 36 via Core Engine