Compound Detail
CHEMBL5723365
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Basic Information
| ChEMBL ID | CHEMBL5723365 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KVJFJJXCBRSCDY-UHFFFAOYSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
400.4
MW (Da)
3.13
ALogP
4
HBA
3
HBD
95.5
PSA (Ų)
0.57
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.77
Kd 2 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone acetyltransferase KAT6A CHEMBL3774298 | Kd | 8.15 | 8.15 | 7.0 | 1 |
| Histone acetyltransferase KAT6A CHEMBL3774298 | IC50 | 7.77 | 7.77 | 17.0 | 1 |
| Histone acetyltransferase KAT7 CHEMBL3774299 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Histone acetyltransferase KAT7 CHEMBL3774299 | Kd | 7.47 | 7.47 | 34.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone acetyltransferase KAT6A | Kd | = | 7.0 | nM | 8.15 | Affinity Biochemical interaction: (SPR) EUB0001094a MYST3 | - |
| Histone acetyltransferase KAT6A | IC50 | = | 17.0 | nM | 7.77 | Affinity Biochemical interaction: (AlphaScreen) EUB0001094a MYST3 | - |
| Histone acetyltransferase KAT7 | IC50 | = | 30.0 | nM | 7.52 | Affinity Biochemical interaction: (AlphaScreen) EUB0001094a MYST2 | - |
| Histone acetyltransferase KAT7 | Kd | = | 34.0 | nM | 7.47 | Affinity Biochemical interaction: (SPR) EUB0001094a MYST2 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5723035 | Histone acetyltransferase KAT7 | 2 |
| - | 10.6019/CHEMBL5723035 | Histone acetyltransferase KAT6A | 2 |
Data from ChEMBL 36 via Core Engine