Compound Detail
CHEMBL5740477
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5740477 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WZKWCGXFVJRERI-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
423.9
MW (Da)
6.00
ALogP
3
HBA
2
HBD
60.8
PSA (Ų)
0.47
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 5.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 CHEMBL4361 | Ki | 5.84 | 5.085 | 1445.0 | 2 |
| Bcl-2-like protein 1 CHEMBL4625 | Ki | 5.53 | 4.92 | 2984.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Ki | = | 1445.0 | nM | 5.84 | fluorescence polarization competition assay (FPCA): Molecular modeling and SILCS... | - |
| Bcl-2-like protein 1 | Ki | = | 2984.0 | nM | 5.53 | fluorescence polarization competition assay (FPCA): Molecular modeling and SILCS... | - |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Ki | = | 46468.0 | nM | 4.33 | fluorescence polarization competition assay (FPCA): Molecular modeling and SILCS... | - |
| Bcl-2-like protein 1 | Ki | = | 49331.0 | nM | 4.31 | fluorescence polarization competition assay (FPCA): Molecular modeling and SILCS... | - |
Data from ChEMBL 36 via Core Engine